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张云武 教授

点击次数:更新时间:2021年11月17日

重庆医科大学客座教授、博士生导师

国家杰出青年科学基金获得者

   学科(专业):神经生物学 细胞生物学

研究方向:神经系统疾病,尤其是阿尔茨海默病和自闭症等疾病的细胞与分子致病机制和药物研发

   邮    箱:yunwuzhang@hotmail.com


工作经历:

    1998年8月-2003年1月  美国Center for Reproduction of Endangered Species, Zoological Society of San Diego访问学者

    2003年2月-11月       美国City of Hope National Medical Center/Beckman Research Center博士后

    2003年11月-2007年4月 美国Sanford-Burnham Medical Research Institute博士后

    2007年5月-至今       厦门大学神经科学研究所 教授,博导, 所长

    2021年7月-至今       重庆医科大学脑科学与脑疾病研究院 客座教授


主要研究领域:

张云武教授从事神经系统疾病,尤其是阿尔茨海默病和自闭症等疾病的细胞与分子致病机制和相关药物研发。在Neuron, PNAS, Biological Psychiatry,Nat Struct Mol Biol等国际著名刊物上发表100多篇研究论文。他荣获国家杰出青年基金、教育部新世纪优秀人才等多项奖项,并担任Molecular Neurodegeneration杂志(SCI IF 14.951)编委。他的研究获得包括国家科技重大专项、973前期专项、国家自然科学基金、美国老年痴呆协会等在内的多项科研项目支持,总额达二千多万元。

实验室主要研究工作包括:1.鉴定参与神经突触功能的新基因蛋白; 2.探究参与神经突触和小胶质细胞功能的基因蛋白在不同神经系统疾病中的参与并阐明其作用机理; 3.靶向疾病相关的关键基因蛋白进行诊断和药物研发。


主要学术成果:

论文

1. Zhang M, Zhou Y, Lu Z, Xiao X, Jiang Y, Ning J, Zhang X, Luo H, Can D, Lu J, Xu H, Zhang YW* (2021) Profiling of Sexually Dimorphic Genes in Neural Cells to Identify Eif2s3y, Whose Overexpression Causes Autism-Like Behaviors in Male Mice. Front Cell Dev Biol. 9:669798.

2. Shen Y, Li L, Xiao X, Yang S, Hua Y, Wang Y, Zhang YW*, Zhang Y* (2021) Site-specific photochemical desaturation enables divergent syntheses of Illicium sesquiterpenes. J Am Chem Soc, 143: 3256-3263.

3. Cheng B, Li X, Dai K, Duan S, Rong Z, Chen Y, Lü L, Liu Z, Huang X, Xu H, Zhang YW*, Zheng H* (2021) Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival. Front Immunol. 12:633796.

4. Zhao D, Zhou Y, Huo Y, Meng J, Xiao X, Han L, Zhang X, Luo H, Can D, Sun H, Huang TY, Wang X, Zhang J, Liu FR, Xu H, Zhang YW* (2021) RPS23RG1 modulates Tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation. Cell Death Differ. 28(1): 337-348.

5. Niu M, Zheng N, Wang Z, Gao Y, Luo X, Chen Z, Fu X, Wang Y, Wang T, Liu M, Yao T, Yao P, Meng J, Zhou Y, Ge Y, Wang Z, Ma Q, Xu H, Zhang YW* (2020) RAB39B deficiency impairs learning and memory partially through compromising autophagy. Front Cell Dev Biol. 8:598622.

6. Meng J, Han L, Zheng N, Xu H, Liu Z, Zhang X, Luo H, Can D, Sun H, Xu H, Zhang YW* (2020) TMEM59 Haploinsufficiency Ameliorates the Pathology and Cognitive Impairment in the 5xFAD Mouse Model of Alzheimer’ s Disease. Front Cell Dev Biol. 8:596030.

7. Liu Z, Ning J, Zheng X, Meng J, Han L, Zheng H, Zhong L, Chen XF, Zhang X, Luo H, Can D, Xu H, Zhang YW* (2020). TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities. Cell Death Dis. 11: 678.

8. Zhao S#, Li Z#, Zhang M, Zhang L, Zheng H, Ning J, Wang Y, Wang F, Zhang X, Gan H, Wang Y, Zhang X, Luo L, Bu G, Xu H, Yao Y, Zhang YW* (2019) A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II. Experimental & Molecular Medicine. 51:84.

9. Zhang X, Huang TY, Yancey J, Luo H, Zhang YW* (2019). Role of Rab GTPases in Alzheimer’s disease. ACS Chem Neurosci. 10(2): 828-838.

10. Zhao D, Meng J, Zhao Y, Huo Y, Liu Y, Zheng Z, Zhang M, Gao Y, Chen Z, Sun H, Wang X, Jing C, Zhang T, Zhang X, Luo H, Wang X, Zhang J, Liu FR, Li Y, Bu G, Wen L, Huang TY, Xu H*, Zhang YW* (2019). RPS23RG1 is Required for Synaptic Integrity and Rescues Alzheimer’s Associated Cognitive Deficits. Biological Psychiatry, 86(3):171-184.

11. Zheng Q, Zheng X, Zhang L, Luo H, Qian L, Fu X, Liu Y, Gao Y, Niu M, Meng J, Zhang M, Bu G, Xu H, Zhang YW* (2017) The neuron-specific protein TMEM59L mediates oxidative stress-induced cell death. Mol Neurobiol, 54(6): 4189-4200.

12. Zhan Y#, Zheng H#*, Wang C#, Rong Z, Xiao N, Ma Q*, Zhang YW* (2016) A Novel presenilin 1 mutation (F388L) identified in a Chinese family with early-onset Alzheimer’s disease. Neurobiol Aging, 50:168.e1-168.e4.

13. Wang C, Niu M, Zhou Z, Zheng X, Zhang L, Tian Y, Yu X, Bu G, Xu H, Ma Q, Zhang YW* (2016) Vps35 regulates cell surface recycling and signaling of dopamine receptor D1. Neurobiol Aging 46: 22-31.

14. Feng T, Niu M, Ji C, Gao Y, Wen J, Bu G, Xu H, Zhang YW* (2016) SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation. Molecular Neurobiology, 53: 3690-3701.

15. Zhang C, Shi Z, Zhang L, Zhou Z, Zheng X, Liu G, Bu G, Fraser PE, Xu H, Zhang YW* (2016) Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology. J Cell Sci 129: 994-1002.

16. Hou P, Liu G, Zhao Y, Shi Z, Zheng Q, Bu G, Xu H, Zhang YW* (2015) The role of copper and the copper-related protein CUTA in mediating APP processing and Ab generation. Neurobiology of Aging 36: 1310-1315.

17. Zhang X, Li Y, Xu H, Zhang YW* (2014) The g-secretase complex: from structure to function. Front Cell Neurosci 8:427.

18. Jiang S#, Li Y#, Zhang X, Bu G, Xu H, Zhang YW* (2014) Trafficking regulation of proteins in Alzheimer’s disease. Mol Neurodegener 9:6.

19. Zhao Y, Wang Y, Yang J, Wang X, Zhao Y, Zhang YW* (2012) Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing. Mol Neurodegener 7:30.

20. Zhao Y, Wang Y, Hu J, Zhang X, Zhang YW* (2012) CutA divalent cation tolerance homolog (E. Coli) (CUTA) regulates β-cleavage of β-amyloid precursor proteins (APP) through interacting with β-site APP cleaving protein 1 (BACE1). J Biol Chem 287: 11141-11150.

21. Huang X, Chen Y, Li W-B, Cohen SN, Liao F-F, Li L, Xu H, Zhang YW* (2010) The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer’s b-amyloid level and tau phosphorylation. Hum Mol Genet 19: 3835-3843.

22. Zhang YW, Xu H (2010) Substrate check of g-secretase. Nat Struct Mol Biol 17: 140-141.

23. Zhang YW#, Liu S#, Zhang X#, Li WB#, Chen Y, Huang X, Sun L, Luo W, Netzer WJ, Threadgill R, Wiegand G, Wang R, Cohen SN, Greengard P, Liao FF, Li L, Xu H. (2009) A functional mouse retroposed gene Rps23r1 reduces Alzheimer’s b-amyloid levels and tau phosphorylation. Neuron 64328-340.

24. Zhang YW*, Wang R, Liu Q, Zhang H, Liao FF, Xu H* (2007) Presenilin/g-secretase-dependent processing of APP regulates EGFR expression. Proc Natl Acad Sci USA 104: 10613-10618. (*: co-corresponding authors)


承担课题

1. 国家自然科学基金区域联合基金重点项目“基于LTP诱导的表达变化的差异来筛选鉴定参与阿尔茨海默病的新基因”(U21A20361,2022.01-2025-12),260万元,主持。

2. 国家自然科学基金重点项目“RPS23RG1调节抑制性神经突触和参与阿尔茨海默病的功能研究”(82130039,2022.01-2026.12),290万元,主持。

3. 国家重点研发计划主动健康和老龄化科技应对重点专项“中国健康长寿大人群多队列的系统研究”项目(2018YFC2000400,2018.12-2022.12),80万元,参与。






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